Jan. 7, 2026

What the Latest Brain Training Science Means for Your Brain Health: A Conversation with the Lead Developer of BrainHQ, Dr. Henry Mahncke, Ph.D.

What the Latest Brain Training Science Means for Your Brain Health: A Conversation with the Lead Developer of BrainHQ, Dr. Henry Mahncke, Ph.D.

In this episode, we explore the science of brain fitness and how targeted brain training exercises can strengthen key brain systems with Dr. Henry Mahncke, Ph.D.. Dr. Mahncke shares his journey from studying neuroscience at UCSF to leading brain plasticity-based training at BrainHQ. 

Learn how BrainHQ’s specific brain training program can improve memory, attention, decision-making, and overall brain resilience across 300+ published research studies. 

Discover the profound impact of brain plasticity, the significance of the groundbreaking INHANCE study, and practical tips on incorporating brain training into your daily life. 

Dr. Mahncke emphasizes that brain training is not just a trend but a scientific approach to maintaining and boosting brain health. 

Tune in to find out how you can intentionally train your brain at any age and better understand the notion of cognitive fitness. 

00:00 Introduction to Brain Fitness

00:24 Meet Dr. Henry Mahncke, Ph.D.

01:46 Personal Motivation and Early Career

03:13 Graduate School and Discovering Brain Plasticity

05:40 The Concept of Brain Fitness

09:19 Brain HQ: The Science Behind Brain Training

11:02 Understanding Brain Fitness and Training

20:50 The Enhanced Study and Neuromodulatory Systems

24:46 Exciting Beginnings: Launching the Study

25:11 Study Design: Brain HQ vs. Ordinary Games

26:18 Training Regimen and Compliance

26:35 Breakthrough Results: Acetylcholine Levels

27:43 Beyond Brain HQ: Broader Brain Health

29:56 The Importance of Intensity in Brain Training

32:58 Holistic Approach to Brain Health

39:45 Practical Tips for Brain Training

42:45 Final Thoughts and Encouragement

Resources

Dr. Henry Mahncke, Ph.D. Profile Photo

CEO of Posit Science / Neuroscientist / Lead Developer of BrainHQ

Henry Mahncke, Ph.D. got his doctorate in neuroscience in the lab at UCSF that discovered the brain remains plastic – capable of chemical, physical and functional change – throughout life. After a stint consulting at McKinsey & Co,. he was recruited to lead the global team commercializing plasticity-based training at Posit Science, which makes BrainHQ. BrainHQ is the most scientifically validated brain training app on the market and has shown benefits in more than peer-reviewed 300 studies. Such benefits include gains in cognition (attention, speed, memory, decision-making), in quality of life (depressive symptoms, confidence and control, health-related quality of life) and in real-world activities (health outcomes, balance, driving, workplace activities). BrainHQ is used by leading health and Medicare Advantage plans, by pre-eminent medical centers, clinics, and communities, and by elite athletes, the military, and other organizations focused on peak performance.