Jan. 7, 2026

What the Latest Brain Training Science Means for Your Brain Health: A Conversation with the Lead Developer of BrainHQ, Dr. Henry Mahncke, Ph.D.

What the Latest Brain Training Science Means for Your Brain Health: A Conversation with the Lead Developer of BrainHQ, Dr. Henry Mahncke, Ph.D.

In this episode, we explore the science of brain fitness and how targeted brain training exercises can strengthen key brain systems with Dr. Henry Mahncke, Ph.D.. Dr. Mahncke shares his journey from studying neuroscience at UCSF to leading brain plasticity-based training at BrainHQ.

Learn how BrainHQ’s specific brain training program can improve memory, attention, decision-making, and overall brain resilience across 300+ published research studies.

Discover the profound impact of brain plasticity, the significance of the groundbreaking INHANCE study, and practical tips on incorporating brain training into your daily life.

Dr. Mahncke emphasizes that brain training is not just a trend but a scientific approach to maintaining and boosting brain health.

Tune in to find out how you can intentionally train your brain at any age and better understand the notion of cognitive fitness.

00:00 Introduction to Brain Fitness

00:24 Meet Dr. Henry Mahncke, Ph.D.

01:46 Personal Motivation and Early Career

03:13 Graduate School and Discovering Brain Plasticity

05:40 The Concept of Brain Fitness

09:19 Brain HQ: The Science Behind Brain Training

11:02 Understanding Brain Fitness and Training

20:50 The Enhanced Study and Neuromodulatory Systems

24:46 Exciting Beginnings: Launching the Study

25:11 Study Design: Brain HQ vs. Ordinary Games

26:18 Training Regimen and Compliance

26:35 Breakthrough Results: Acetylcholine Levels

27:43 Beyond Brain HQ: Broader Brain Health

29:56 The Importance of Intensity in Brain Training

32:58 Holistic Approach to Brain Health

39:45 Practical Tips for Brain Training

42:45 Final Thoughts and Encouragement

Resources

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Welcome to the Let's Talk Brain
Health podcast, a public health

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educational initiative of the
virtual Brain Health Center.

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I'm your host, Doctor Crystal
Color, and I'm so glad you're

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here.
On this podcast, I sit down with

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incredible guests to explore all
things brain health and

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Wellness.
Together, we'll talk about how

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to care for your total brain
health, mind, body, and spirit

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while sharing the latest brain
Health Science practical tips

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and strategies you can use
everyday.

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By prioritizing your brain
health, you're taking an

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important step towards living a
happier, healthier life.

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So let's dive in and welcome
today's guest.

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Keeping your brain sharp isn't
just about doing puzzles or

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playing games.
Targeted brain exercises can

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actually strengthen key brain
systems, improve memory,

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attention and decision making,
and even help your brain stay

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resilient as you age.
Today we're diving into the

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science of brain fitness and how
the right kind of brain training

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to make a real difference in
your everyday life.

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Doctor Henry Monka got his
doctorate in neuroscience in the

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lab at UCSF that discovered the
brain remains plastic, capable

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of chemical, physical and
functional change throughout

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life.
After a stint consulting at

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McKenzie and Co, he was
recruited to lead the global

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team commercializing plasticity
based training at Posit Science

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which makes Brain HQ Drainage.
Q is the most scientifically

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validated brain training app on
the market and has shown

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benefits in more than 300
reviewed studies.

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Such benefits include gains in
cognition, attention, memory,

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speed, decision making and
quality of life, depressive

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symptoms, confidence and
control, health related quality

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of life, and real world
activities including health

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outcomes, balance, driving and
workplace activities.

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BRING HQ is used by leading
health and Medicare Advantage

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plans, by preeminent medical
centers, clinics and

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communities, and by elite
athletes, the military and other

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organizations.
Focus on peak performance if

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we're going to talk brain
fitness, I can't think of

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another brilliant brain to.
Welcome to the podcast today,

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Henry.
Is there any additional

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information about your
background that you'd like to

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share with our audience?
First of all, Crystal, it's

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really nice to be talking with
you on the podcast today.

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Thank you for the invitation and
the boy that did seem like a

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pretty comprehensive biography.
I will add to it, Ed, your

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invitation, which is, hey, one
thing that's not in that

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biography is one of the reasons
I'm doing this work is because

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of my grandfather.
So I'm actually named after my

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grandfather.
His name was also Henry Monka,

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and he passed away in 1980 of
Alzheimer's disease when I was a

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kid at that age.
It's amazing.

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If you look back at that time,
the 70s and the early 80s, we

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didn't really know anything
about brain health.

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They didn't even call it
Alzheimer's disease, right?

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They just said he passed away of
senile dementia.

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He may have heard that term.
We don't use that term anymore,

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but that's how it's described.
And I just remember going

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through that with my family and
my dad in particular, and having

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had the amazing opportunity to
come out and do a PhD in

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neuroscience.
And I'll be doing this work in

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brain health.
It's wonderful and amazing thing

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to do to come to work everyday
and work on something that

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afflicted my grandfather and
then so many other people as

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well.
So I'll add that to my bio.

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I appreciate you sharing that
personal connection.

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It seems so many other people
enter the field with some type

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of connection with a loved one
in brain health.

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I think broader statistics show
8 out of 10 Americans are

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directly or indirectly impacted
by broader brain health

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concerns.
But I do have to ask, what

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brought you to focus
specifically on this cognitive

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training component that you have
honestly dedicated your entire

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career to this?
Yeah, that's a wonderful

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question and really starts when
I came to Graduate School.

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I came out to Graduate School to
the University of California,

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San Francisco, and like almost
everyone who starts in Graduate

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School, I wanted to go to study
neuroscience because I wanted to

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understand the mysteries of how
the brain works.

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I think every graduate student
in neuroscience starts in that

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exact same place.
Like, it's amazing, right?

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3 1/2 lbs of wet goo inside your
skull gives rise to every

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conscious experience and memory
and the life event that's going

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to happen to you.
And I joined a really remarkable

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lab at UCSF.
I worked in the lab of Doctor

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Michael Mersnick, who's world
famous in the world of

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neuroscience, which my parents
remind me means nobody has ever

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heard of him.
But nonetheless, what Mike is

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really credited for is this
discovery of adult brain

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plasticity, right?
He fundamentally discovered that

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the adult brain can change and
rewire itself.

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And when I started Graduate
School, which again was a long

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time ago, but when I started
Graduate School, we were told

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over and over again that, hey,
the brain builds itself when

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you're a kid.
But sometime after the age of 7

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or 12 or 19, no one really knew
quite when your critical period

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is over, your brain wiring is
done.

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Your brain is now like a
computer with fixed wiring.

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And we were told over and over
again, all it does is wear out

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over time like any kind of
machine.

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And that's what happens as we
get old.

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And I remember to this day being
in the UCSF library and opening

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up proceedings, the National
Academy of Sciences, and

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discovering for the first time
that new brain cells could be

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born in the adult brain.
That work was actually done in

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songbirds, first of all things,
and joining Mike Mersnick Lab,

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which really turned that whole
idea on its head.

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Work from Mike and then his
students and then people all

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over the world showed us that
none of that's true.

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The adult brain can reorganize
and rebuild itself.

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I finished my graduate work.
I decided I didn't want to be a

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professor.
I worked in consulting, as you

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mentioned.
I worked for the British

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government for a period of time
on science and technology

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policy.
But one day, Mike called me up,

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and he said, Henry, we've helped
a lot of rats build better

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brains.
We've helped a lot of monkeys

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build better brains.
Don't you think it's about time

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to help people build some better
brains?

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And I thought about my
grandfather, and I thought about

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the fact that I lived in San
Francisco, and everyone here

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needs to join a startup sooner
or later.

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And that's what kicked me off on
this path.

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And really today that's a myth
of the brain.

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I think we're still debunking,
correct, is that adult brains

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still have this ability to grow
and change and re sculpt.

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And I think that's a great way
to kick off the conversation

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with you a bit is what exactly
is this idea of brain fitness or

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cognitive fitness and brain
training?

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Before we dive into the crux of
the conversation with you and

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focusing on your work at Brain
HQ, could you tell us what that

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idea of that concept is?
Because it does build off of

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brain plasticity.
But what is this idea of brain

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fitness?
You put it absolutely perfectly,

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which is, hey, we have
recognized from thousands and

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thousands of scientific
publications that the brain is

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plastic.
And that's a funny term, but

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scientists use this term to mean
that the brain can change

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itself, it can build new
connections, it can change its

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structure, its function, its
chemistry and its health in that

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way.
And that's science that's,

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again, really been around since
the 90s and the 2000s.

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But the implications of that
science are only now finally

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becoming clear.
And what I mean by that is once

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you really appreciate brain
plasticity, appreciate that,

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hey, this is how the brain
works.

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Your brain rebuilds itself in
response to what you ask it to

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do.
And hey, that happens when

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you're a little kid and it
happens when you're middle-aged.

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It happens when you're old.
It happens when your brain is

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healthy.
It happens when your brain is

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unhealthy.
It's just the fundamental

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operation of the brain is it's a
machine that's continuously

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rebuilding and reorganizing
itself.

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As soon as that idea really
sinks in, you immediately

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recognize, hey, if I ask the
brain to do the right kinds of

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things, I could probably build
the right kinds of connections

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and the right kinds of
structures and the right kind of

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chemistry.
And if I could rebuild the brain

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in that way, maybe I could make
a brain that was healthier or

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sharper or worked better.
And it was that fundamental idea

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that, hey, we could take this
basic science of brain

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plasticity, publish again
thousands of scientific papers.

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We're going to fill up a
library, right?

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And could turn it into an
applied science.

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Or anyone, you or me or anyone
we know could take advantage of

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this scientific breakthrough to
help make their own brain

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healthier.
That's what the fundamental idea

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is.
Put it another way, we've had a

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physical fitness revolution,
right?

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50 years ago, we all started to
recognize that, hey, if we did

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the right kind of physical
exercise, like, we would improve

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our bodily health.
And if we improved our bodily

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health, we'd have a better life,
right?

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We'd live longer and happier and
healthier.

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But weirdly, that insight
stopped at the neck.

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Everyone recognizes, hey, of
course you can do things to take

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care of your physical health.
And we never quite made the next

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logical step, which is, gosh,
shouldn't we be able to take

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care of our brain health as
well?

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And I think that's because
people have a little bit of a

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funny idea about the brain,
right?

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If you talk to most people about
the brain, they have a very

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psychological or spiritual view
of the brain, which is fine.

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I get it completely right.
The brain is our source of

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consciousness and our memories
and our spirit and our hopes and

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dreams of the future and our
memories of the past.

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But you and I both know that
it's also 3 1/2 lbs of wet goo

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that sits inside your skull.
And hey, it can be healthier or

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less healthy.
Just like your heart can be

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healthier or less healthier.
Just like your liver can be

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healthier or less healthy.
And in the same way we've gotten

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a sense of how to control the
health of our bodily systems,

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now we are finally recognizing,
hey, to some extent, we have

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some control over the health of
our brain systems as well.

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And that's incredibly exciting.
It is a time that's exciting, I

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think from so many times when
I've done talks about brain

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health and Wellness in general
and people always like, what's

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your top tip?
And I'm like one that's really

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hard to do.
But I parallel what you're

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saying is this idea that we have
this idea of what physical

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fitness is, but what's brain
fitness?

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And if we can build off this
idea that you have this fitness

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routine for your physical body,
what does that look like for

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your brain?
You work at Brain HQ.

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So this is the great segue for
me to ask you of what exactly is

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Brain HQ?
Because this is one way that has

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a large science behind it.
You have over 300 research

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studies, years of research
behind this, that if people

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really want to find an evidence
based tool and research to build

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out this idea of what brain
fitness could look like from

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them, this may be a really
strong evidence based point to

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start.
So can you tell us about what

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Brain HQ is and what all domains
of the brain does it challenge?

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Let's build off on exactly what
you were saying.

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Hey, what does physical fitness
mean?

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I think we could all agree that,
hey, you know, what physical

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fitness means is that our body
can do the things that it's

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designed to do and that we want
it to do.

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We can walk a long distance, we
can climb stairs, we can swim,

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or we can move about, or we can
pick up our kids, right?

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We have that sense.
It can do what it's supposed to

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do.
We have exactly the same sense

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for brain fitness.
What does it mean to have a fit

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brain?
What is brain fitness?

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It means a brain can do the
things that our brain is

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supposed to to do.
So what's our brain supposed to

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do?
Supposed to pay attention.

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It's supposed to hold things in
memory.

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It's supposed to make good
decisions and think for us,

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right?
And it's supposed to control our

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body effectively.
And so that's what we mean by

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brain fitness.
You have a fit brain if you can

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do those things quite well.
And hey, you have a less fit

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brain.
If you don't, that raises a

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natural question.
Okay, Given that we can clearly

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see that some people have fitter
brains for whatever reasons, and

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some people don't, hey, how
could we manipulate that?

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And in particular, if we have
this idea that the brain is

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plastic, it can be rewired, How
can we ask the brain to do

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things that are going to move it
from a less fit to a more fit

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direction?
And the answer here is just a

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tiny bit more complicated than
physical fitness, right?

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With physical fitness, just
about everything you do to some

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extent is going to help your
physical fitness, right?

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And This is why most physical
activity guidelines are pretty

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broad.
Find something you like to walk,

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you like to run, you like to
swim.

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Hey man, pick one and do it.
That's all great.

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Bring fitness.
Just a tiny bit more

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complicated.
And I'm sure we'll dig into this

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in some more depth.
To get a handle on this, you

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have to start to ask, hey, what
makes a brain that is not so

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good at attention or working
memory executive function

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different from a brain that is?
And it turns out that it's very

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clear that brains that are not
so great are noisy.

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And what do I mean by noisy?
What I mean is this right?

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Imagine your brains, an old
radio.

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And if you remember old radios,
you used to be able to tune

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them.
And if you could tune onto the

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radio station, you could hear
the music and the DJ saying

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everything very clearly.
But if you were just a little

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bit off, there would be static,
there would be noise, right?

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Harder to hear what's being
said, harder to hear the music.

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And as a result, you might be
listening to the radio and you

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don't pay attention to it as
well.

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It's harder to remember what the
DJ says.

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Harder to get home and think,
oh, what was that song that I

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heard?
And that's because that noise

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interferes with cognitive
processing.

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Turns out that as we get older,
but frankly also in virtually

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every neurological and
psychiatric condition, the brain

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has internal noise or static.
And we can see that when

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experiments in the lab in all
kinds of ways.

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If you ask young people to
remember words, they can

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remember a lot of words, but if
you introduce external noise,

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they can remember fewer words.
Take a young person and you can

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give them the cognitive
abilities of an old person just

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by introducing noise.
And all kinds of other

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psychophysical evidence points
this out.

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So we know that older brains are
noisy in this way, and they're

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noisy and they're hearing and
they're noisy and their vision.

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And that's actually what's
contributing to problems and

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attention and working memory and
executive function.

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So with that observation, the
question becomes with the idea

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of brain plasticity, how can we
take a noisy system and make it

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a high performing system?
How can we improve the signal to

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noise ratio in the brain, one
might say, so more signals

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getting through with less noise
so we can think faster and

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00:13:34,320 --> 00:13:37,400
better and more clearly.
Turns out you can do that by

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asking the brain to be more fast
and accurate.

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00:13:40,400 --> 00:13:43,280
What do I mean by that?
So this is not about teaching

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tips.
It's not about, hey, when you

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00:13:44,880 --> 00:13:47,920
meet someone, rhyme their name
so you have a mnemonic for it.

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And really we're trying to
rebuild the machinery of the

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brain in a very bottom up way.
So how can we ask the brain to

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be faster?
We build computerized brain

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00:13:56,640 --> 00:14:01,240
training exercises that are
adaptive and require fast,

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00:14:01,240 --> 00:14:04,160
accurate information processing
to do them correctly.

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We're on a podcast.
I can give you an auditory

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00:14:06,600 --> 00:14:09,040
example if you like.
Sure, that would be great.

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00:14:09,240 --> 00:14:10,880
All right, I'm going to do my
best to whistle.

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So one of the first brain
training exercises we built,

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because we had done this in rats
back in the day, was an exercise

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00:14:16,840 --> 00:14:18,440
where you hear 2 little whistle
sounds.

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00:14:18,960 --> 00:14:21,760
And for each one you have to
decide does it go up or does it

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00:14:21,760 --> 00:14:23,880
go down.
So you might hear hope that got

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00:14:23,880 --> 00:14:27,000
throughout the podcast, and then
you might hear one that went

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00:14:27,000 --> 00:14:29,640
down.
Now, hey, if you hear a big slow

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00:14:29,640 --> 00:14:31,880
one that goes up and a big slow
one that goes down, hey,

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everybody can hear.
There's two of them.

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00:14:33,520 --> 00:14:36,200
Everyone can hear the first one
swept up and the second one

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00:14:36,200 --> 00:14:38,680
swept down.
OK, if you get that, let's make

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00:14:38,680 --> 00:14:40,920
it a little bit faster because
we're trying to train your brain

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to be faster.
So we'll make them shorter.

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And as that happens, you can
typically keep doing it, but

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everyone sooner or later gets to
a speed where they can no longer

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00:14:49,440 --> 00:14:50,880
do it.
You just can't hear that there

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00:14:50,880 --> 00:14:53,520
are two of them anymore.
Scientists call that masking

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00:14:53,520 --> 00:14:55,960
forward or backward masking.
Or if you hear that there are

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00:14:55,960 --> 00:14:57,960
two, you heard that there were
two, but you're not sure which

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00:14:57,960 --> 00:15:00,040
one came first.
Were both of them down or was

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00:15:00,040 --> 00:15:02,480
one of them up?
So as soon as that happens, we

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00:15:02,480 --> 00:15:04,480
back off, we make the sound
slower again.

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00:15:04,680 --> 00:15:08,600
So we find your unique brains
speed there for your threshold,

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00:15:08,600 --> 00:15:11,320
so to speak, and we ask you to
work at that level.

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00:15:11,600 --> 00:15:13,640
And what's important about it is
it's adaptive.

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You're going to be at a level
where you get a lot of them, but

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00:15:16,000 --> 00:15:17,920
you're always going to get some
of them wrong.

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00:15:18,200 --> 00:15:21,920
And we do that because in order
to drive brain plasticity can't

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00:15:21,920 --> 00:15:23,880
be too easy, right?
If you're doing something that's

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00:15:23,880 --> 00:15:26,240
too easy, you get 100% right.
That feels great.

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00:15:26,240 --> 00:15:28,640
I guess people like to get
everything right, but hey, your

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00:15:28,640 --> 00:15:31,640
brain doesn't need to change if
you can get everything right.

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00:15:31,880 --> 00:15:34,560
So it's got to be harder than
that, but it can't be too hard

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00:15:34,720 --> 00:15:36,920
if it's so hard that you get
most of them wrong.

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00:15:37,080 --> 00:15:39,560
It's like trying to climb a
Cliff face and you can't get a

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00:15:39,560 --> 00:15:42,120
handhold on it, right?
Your brain can't quite get a

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00:15:42,120 --> 00:15:44,200
handle on how to do it.
So your brain also doesn't

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00:15:44,200 --> 00:15:46,160
rewire.
So you have to maintain this

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00:15:46,160 --> 00:15:49,040
adaptive control where it's
exactly the right level of

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00:15:49,040 --> 00:15:51,120
difficulty for each person's
unique brain.

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00:15:51,440 --> 00:15:54,800
And if you do that today and
then you do it tomorrow and then

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00:15:54,800 --> 00:15:57,120
you do it the next day, hey,
you're going to start to get

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00:15:57,120 --> 00:15:59,760
better at this task.
Just in the same way, if you

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00:15:59,760 --> 00:16:02,640
were practicing French or
learning the piano or learning

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00:16:02,640 --> 00:16:05,800
how to kick a soccer, brain
plasticity is going to drive

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00:16:05,800 --> 00:16:07,000
learning.
You're going to get better at

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00:16:07,000 --> 00:16:09,440
this task.
So if you do that for a while,

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00:16:09,440 --> 00:16:11,680
your brains going to get faster
at hearing these little

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00:16:11,680 --> 00:16:13,560
whistles.
And then you might ask, OK,

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00:16:13,560 --> 00:16:15,720
Henry, that's great, but I don't
really care about whistles,

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00:16:15,920 --> 00:16:17,480
right?
Why would you give me a brain

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00:16:17,480 --> 00:16:19,920
training exercise that did
nothing but make me faster at

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00:16:19,920 --> 00:16:22,480
hearing these whistles?
The reason we pick that is

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00:16:22,480 --> 00:16:25,600
because that kind of sound is
actually incredibly important

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00:16:25,600 --> 00:16:28,400
for human speech.
So we can all do this together.

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00:16:28,400 --> 00:16:30,320
Everyone who's listening to the
podcast can do this.

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00:16:30,520 --> 00:16:33,360
If you take your thumb and your
index finger and you put them on

359
00:16:33,360 --> 00:16:35,920
your voice box right here on
your throat, and you make a

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00:16:35,920 --> 00:16:41,040
sound like BA, like a baby BA.
You do that a couple times, feel

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00:16:41,040 --> 00:16:43,600
when your lips open and feel
when your voice box starts to

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00:16:43,600 --> 00:16:46,280
vibrate.
BA, your lips open and your

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00:16:46,280 --> 00:16:48,800
voice box starts to vibrate at
exactly the same time.

364
00:16:49,440 --> 00:16:51,040
But now I'm going to ask you to
make a different sound.

365
00:16:51,040 --> 00:16:53,640
Put that thumb and that index
finger on your voice box again

366
00:16:53,920 --> 00:16:57,800
and make the sound Pennsylvania,
like my Papa, My Papa.

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00:16:58,280 --> 00:17:02,280
When you do that, Pennsylvania,
your lips open just a little bit

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00:17:02,280 --> 00:17:04,160
before your voice box starts to
vibrate.

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00:17:04,480 --> 00:17:07,200
Now that may seem like a very
small difference, but that

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00:17:07,200 --> 00:17:09,440
little gap, it's called a voice
onset time.

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00:17:09,440 --> 00:17:11,440
And you're going to be thrilled
to know that there are hundreds

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00:17:11,440 --> 00:17:14,079
of scientists all over the world
that study this as their primary

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00:17:14,079 --> 00:17:16,880
field of research.
And that gap is the difference

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00:17:16,880 --> 00:17:20,359
between a BA and a PA.
So if your brain can process

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00:17:20,359 --> 00:17:23,280
information really quickly and
accurately, you'll hear that

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00:17:23,280 --> 00:17:25,240
little gap.
And you can hear the difference

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00:17:25,240 --> 00:17:27,400
between someone saying a BA and
a Pennsylvania.

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00:17:27,680 --> 00:17:30,440
But if you can't, if you're
older and your brain is slowed

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00:17:30,440 --> 00:17:33,440
down, or maybe you've had a
concussion, or maybe you've had

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00:17:33,440 --> 00:17:36,720
cancer treatment or maybe you've
had COVID and your brain is

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00:17:36,720 --> 00:17:38,960
slower and noisy, you can't hear
that little gap.

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00:17:39,280 --> 00:17:41,560
Everything you hear is going to
sound smushed together and

383
00:17:41,560 --> 00:17:43,200
you're not going to be able to
tell the difference between

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00:17:43,200 --> 00:17:46,480
those Bahs and Bahs as OK, now
you're not getting good quality

385
00:17:46,480 --> 00:17:48,800
information in your brain.
It's harder to pay attention to

386
00:17:48,800 --> 00:17:51,880
what someone says, harder to
remember it, harder to act on.

387
00:17:52,200 --> 00:17:54,920
So by improving your brain speed
with those weird little

388
00:17:54,920 --> 00:17:57,760
whistles, we actually start to
turn your brain into a better

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00:17:57,760 --> 00:17:59,880
information processor for human
speech.

390
00:18:00,120 --> 00:18:02,680
So you can remember when you're
going to the store and your

391
00:18:02,680 --> 00:18:05,280
partner says, hey, pick up some
eggs and some celery and some

392
00:18:05,280 --> 00:18:07,200
milk.
All that information gets in

393
00:18:07,200 --> 00:18:09,040
your brain better and faster.
It gets stored.

394
00:18:09,040 --> 00:18:11,280
And when you're at the grocery
store, you have a better memory.

395
00:18:11,720 --> 00:18:14,160
That's the idea behind these
Brain HQ exercises.

396
00:18:14,160 --> 00:18:17,280
There are dozens of exercises
targeting all kinds of areas of

397
00:18:17,280 --> 00:18:19,600
the brain.
Fundamentally, each one of them

398
00:18:19,600 --> 00:18:22,320
is designed to make brain
information processing faster

399
00:18:22,320 --> 00:18:25,760
and more accurate, and in doing
so, improve your brain's ability

400
00:18:25,760 --> 00:18:28,840
to process information and then
do things like attend and

401
00:18:28,840 --> 00:18:31,720
remember and act.
So they all start to lead to

402
00:18:31,720 --> 00:18:35,600
real world applications.
It's not just this arbitrary.

403
00:18:36,000 --> 00:18:39,600
Hey, you have this game and it
might just work out memory but

404
00:18:39,600 --> 00:18:42,760
doesn't actually help you in
your day-to-day life.

405
00:18:43,240 --> 00:18:46,560
Yeah, that's exactly right.
The art, if I may say so, and

406
00:18:46,560 --> 00:18:50,480
then certainly the science of
building these exercises is just

407
00:18:50,480 --> 00:18:55,160
look at the real world stimuli
one might say that a person has

408
00:18:55,160 --> 00:18:57,040
to interact with.
What is it important for a

409
00:18:57,040 --> 00:19:00,560
person to hear and remember?
Largely human speech, and we

410
00:19:00,560 --> 00:19:03,640
know a lot about kind of the
acoustics of human speech.

411
00:19:03,880 --> 00:19:06,920
So we can build these very
elemental exercises that mimic

412
00:19:06,920 --> 00:19:09,400
these aspects of a human speech
to build a better speech

413
00:19:09,400 --> 00:19:11,680
information processor or
envision.

414
00:19:11,680 --> 00:19:14,800
We can ask ourselves again, hey,
what are the statistics, one

415
00:19:14,800 --> 00:19:17,800
might say, of the visual things
that one encounters, right?

416
00:19:17,800 --> 00:19:20,000
Things in the center of your
vision and your peripheral

417
00:19:20,000 --> 00:19:22,440
vision, right?
And then you can build exercises

418
00:19:22,440 --> 00:19:26,680
that kind of start off with
these big bold stimuli that pop

419
00:19:26,680 --> 00:19:28,320
out.
They're processed by the brain

420
00:19:28,320 --> 00:19:30,640
really easily.
They drive a lot of synchronous

421
00:19:30,800 --> 00:19:34,120
activity across the brain.
But gradually you can fade into

422
00:19:34,120 --> 00:19:37,040
very naturalistic scenes where
it's hard to see things and

423
00:19:37,280 --> 00:19:39,680
things are more confusing with
each other and they don't pop

424
00:19:39,680 --> 00:19:42,640
off Balkans background.
So you can guide the brain into

425
00:19:42,640 --> 00:19:45,640
these naturalistic environments
and then build a brain

426
00:19:45,640 --> 00:19:47,920
information processor that, hey,
just works better.

427
00:19:47,920 --> 00:19:50,680
For example, when you're out
driving so that when you, let's

428
00:19:50,680 --> 00:19:53,560
say, roll up to a stop sign and
to dusk and right, and there's

429
00:19:53,560 --> 00:19:56,560
not great visual information.
Nonetheless your peripheral

430
00:19:56,560 --> 00:19:59,320
vision is acting quickly and
accurately so that if a car is

431
00:19:59,320 --> 00:20:02,080
about to hop in from the other
intersection, you're going to

432
00:20:02,080 --> 00:20:05,680
see it before you get in.
Each task is built on getting

433
00:20:05,680 --> 00:20:08,400
your brain to process real
information, but in this very

434
00:20:08,400 --> 00:20:10,560
bottom up kind of step by step
way.

435
00:20:11,040 --> 00:20:13,280
And in that way you can think
about it like, let's say you

436
00:20:13,280 --> 00:20:15,360
were an NBA player.
One thing you're going to do is

437
00:20:15,360 --> 00:20:17,600
practice playing basketball.
That's an important skill to be

438
00:20:17,600 --> 00:20:20,000
in the NBA.
But hey, your physical trainer

439
00:20:20,000 --> 00:20:22,160
is also going to have you go to
the gym and they're going to

440
00:20:22,160 --> 00:20:25,720
decompose every single thing you
need to do to win a basketball

441
00:20:25,720 --> 00:20:28,080
game.
And to, hey, I need to exercise

442
00:20:28,080 --> 00:20:31,000
your bicep this way, and I need
you to exercise your legs this

443
00:20:31,000 --> 00:20:33,320
way, and I need you to exercise
your core that way.

444
00:20:33,760 --> 00:20:35,840
And by building up those
individual muscles, hey, when

445
00:20:35,840 --> 00:20:39,080
you get out on the court, you
now have the physical ability

446
00:20:39,080 --> 00:20:42,680
now to be a winning NBA player.
Brain HQ exercises are intended

447
00:20:42,680 --> 00:20:45,360
to work the same way.
We decompose these real world

448
00:20:45,360 --> 00:20:48,560
cognitive things you have to do
into these very elemental tasks.

449
00:20:48,800 --> 00:20:51,720
You exercise at them, you get
better through brain plasticity.

450
00:20:51,880 --> 00:20:53,800
And then, hey, when you're out
in the world, you just have a

451
00:20:53,800 --> 00:20:56,120
better system to interact with
all of the things that are

452
00:20:56,120 --> 00:20:58,920
coming into you in the world.
And I'm so grateful for the

453
00:20:58,920 --> 00:21:01,480
examples you've shared because
across your studies, you have

454
00:21:01,480 --> 00:21:04,440
studied with this from elite
athletes, but also to your

455
00:21:04,440 --> 00:21:07,600
average adults.
And it leads to an important

456
00:21:07,600 --> 00:21:10,440
study that recently came out,
your enhanced study.

457
00:21:10,720 --> 00:21:13,400
So can you tell us a little bit
about what was that study

458
00:21:13,400 --> 00:21:17,200
designed to test and what is so
exciting about its results that

459
00:21:17,200 --> 00:21:20,120
is grabbing people's attention
in the headlines?

460
00:21:20,600 --> 00:21:23,480
Yeah, the enhanced study has
just had an amazing set of

461
00:21:23,480 --> 00:21:26,480
results.
And you know, where it came from

462
00:21:26,480 --> 00:21:29,600
is when we started building
these brain training exercises,

463
00:21:29,960 --> 00:21:32,840
in a way, we thought of them as
cognitive training, a little bit

464
00:21:32,840 --> 00:21:34,760
like I just talked you through.
We thought, hey, we're going to

465
00:21:34,960 --> 00:21:38,320
train these cognitive skills the
way a psychologist might

466
00:21:38,320 --> 00:21:42,560
recognize, like basic aspects of
attention or memory or executive

467
00:21:42,560 --> 00:21:45,240
function, but always at the same
time, right?

468
00:21:45,240 --> 00:21:47,240
We really came from a world of
neuroscience.

469
00:21:47,240 --> 00:21:49,840
We thought about the brain as
those 3 1/2 lbs of wet goo

470
00:21:49,840 --> 00:21:53,840
inside your skull and we thought
hey, we can improve information

471
00:21:53,840 --> 00:21:55,560
processing in the way that I
talked about.

472
00:21:55,560 --> 00:21:58,200
We can improve sickle to noise
ratios and so forth and so on.

473
00:21:58,520 --> 00:22:01,640
But the very inception Doctor
Mike Mersnick, our my PhD

474
00:22:01,640 --> 00:22:04,760
advisor and our founder said,
hey, we are absolutely going to

475
00:22:04,760 --> 00:22:06,160
be doing a second set of things
here.

476
00:22:06,160 --> 00:22:08,360
He said we're going to be
improving the health of the

477
00:22:08,360 --> 00:22:12,320
brains neuromodulatory system.
And what he meant by that is

478
00:22:12,320 --> 00:22:15,560
hey, the brain's got these
amazing systems that release

479
00:22:15,560 --> 00:22:18,760
certain kinds of neurochemicals
and these neurochemicals are

480
00:22:18,760 --> 00:22:21,520
broadly distributed across the
brain and they contribute to

481
00:22:21,520 --> 00:22:24,520
broad aspects of brain state and
brain health.

482
00:22:24,840 --> 00:22:27,400
For example, a lot of people
perhaps have heard of serotonin,

483
00:22:27,400 --> 00:22:30,000
which is involved in mood and
depressive disorders.

484
00:22:30,280 --> 00:22:33,320
You have these serotonergic
nerves that connect all over the

485
00:22:33,320 --> 00:22:35,200
brain and release serotonin at
the right time.

486
00:22:35,520 --> 00:22:37,880
People may have heard of
dopamine, similar kind of system

487
00:22:37,880 --> 00:22:40,960
projects across the entire
brain, releases dopamine to be

488
00:22:40,960 --> 00:22:43,240
enforced to the brain that, hey,
when you did something your

489
00:22:43,240 --> 00:22:46,200
brain likes, you should
reorganize the brain to do more

490
00:22:46,200 --> 00:22:47,640
of it.
There's a system called

491
00:22:47,640 --> 00:22:49,760
acetylcholine, which is involved
in attention.

492
00:22:49,760 --> 00:22:51,600
Every time you're paying
attention, your brain's

493
00:22:51,600 --> 00:22:54,640
releasing acetylcholine and that
actually gives a signal to the

494
00:22:54,640 --> 00:22:57,080
brain that it's a good time to
rewire itself because hey,

495
00:22:57,080 --> 00:22:58,840
you're paying attention to
something important.

496
00:22:59,280 --> 00:23:02,760
So at the very beginning, 20
years ago, Mike said, hey, as

497
00:23:02,760 --> 00:23:05,360
well as improving the
information processing abilities

498
00:23:05,360 --> 00:23:08,640
of the brain, we're probably
rebuilding the health of these

499
00:23:08,640 --> 00:23:12,360
neuromodulatory systems.
Now at the time we thought maybe

500
00:23:12,960 --> 00:23:15,360
there was some evidence for this
in rats, but certainly no one

501
00:23:15,360 --> 00:23:17,000
had ever seen this in humans
before.

502
00:23:17,360 --> 00:23:20,080
So the enhanced study was
designed to finally put that

503
00:23:20,080 --> 00:23:22,680
idea to the test.
Could these kinds of brain

504
00:23:22,680 --> 00:23:25,680
training exercises, again,
designed to improve these

505
00:23:25,680 --> 00:23:28,760
fundamental cognitive skills,
could they have a deeper effect

506
00:23:28,760 --> 00:23:32,200
on almost the health of the
brain as a biological organ by

507
00:23:32,200 --> 00:23:34,640
improving how these
neuromodulatory systems work?

508
00:23:35,160 --> 00:23:37,600
We had the opportunity to work
with an incredible collaborative

509
00:23:37,600 --> 00:23:41,560
group up in McGill in Canada at
Tian de Villar Sadani, and that

510
00:23:41,560 --> 00:23:45,040
group had come up with something
truly remarkable, which is a way

511
00:23:45,040 --> 00:23:47,960
to image the health of the
acetylcholine system in the

512
00:23:47,960 --> 00:23:49,680
human brain.
And here's the good news.

513
00:23:49,680 --> 00:23:52,400
To do that without cracking your
skull open and putting a needle

514
00:23:52,440 --> 00:23:55,160
in it, right?
They had a very specific marker

515
00:23:55,160 --> 00:23:56,920
that they can inject into a
person.

516
00:23:57,040 --> 00:24:00,040
And that marker would
essentially glom onto or stick

517
00:24:00,040 --> 00:24:02,920
to this aspect of the brain's
acetylcholine system.

518
00:24:02,920 --> 00:24:05,080
And you can image it using a
technique called PET imaging.

519
00:24:05,560 --> 00:24:07,720
So for the first time, we could
just look and see how healthy is

520
00:24:07,720 --> 00:24:10,760
a person's cholinergic system.
And before we started these

521
00:24:10,760 --> 00:24:14,080
studies, that group had already
shown that, hey, the cholinergic

522
00:24:14,080 --> 00:24:17,960
system declines by about 2 1/2%
per year from the ages of 20 to

523
00:24:17,960 --> 00:24:20,560
60 or 70.
And we knew also that, hey, it

524
00:24:20,560 --> 00:24:23,560
actually declines quite rapidly
with the onset of Alzheimer's

525
00:24:23,560 --> 00:24:26,400
disease and dementia.
And in fact, if you go back to

526
00:24:26,400 --> 00:24:29,320
the 90s and look at what
Alzheimer's researchers working

527
00:24:29,320 --> 00:24:32,320
on, the decline of the
acetylcholine system in the

528
00:24:32,320 --> 00:24:34,960
brain was one of the earliest
signs of Alzheimer's and

529
00:24:34,960 --> 00:24:36,840
dementia.
It falls off quite rapidly.

530
00:24:37,120 --> 00:24:40,320
And that loss of acetylcholine
is probably why those memory and

531
00:24:40,320 --> 00:24:43,120
thinking and attention problems
emerge in Alzheimer's disease.

532
00:24:43,440 --> 00:24:45,800
And in fact, the first
Alzheimer's drugs, if you think

533
00:24:45,800 --> 00:24:48,200
of things like Aricept, they
were drugs that were

534
00:24:48,200 --> 00:24:51,200
fundamentally designed to help
more acetylcholine stay around

535
00:24:51,200 --> 00:24:53,880
in the brain, right?
And those had some limited

536
00:24:53,880 --> 00:24:56,520
positive effects.
So we've asked this question in

537
00:24:56,520 --> 00:24:59,480
a beautiful gold standard
randomized controlled trial.

538
00:24:59,720 --> 00:25:02,560
Hey, does this kind of brain
training and brain HQ, does it

539
00:25:02,560 --> 00:25:04,840
help improve the health of the
acetylcholine system?

540
00:25:05,120 --> 00:25:07,080
And I got to tell you, Crystal,
we were very excited to start

541
00:25:07,080 --> 00:25:10,000
this study and I simply did not
know what we were going to see.

542
00:25:10,000 --> 00:25:12,320
Most studies, we have a pretty
strong idea of what we're going

543
00:25:12,320 --> 00:25:14,080
to see, certain kinds of
cognitive improvement or health

544
00:25:14,080 --> 00:25:16,080
improvement.
But this was really a shot out

545
00:25:16,080 --> 00:25:18,760
there into the unknown.
What happened in the study was

546
00:25:18,760 --> 00:25:20,360
funded by the National
Institutes of Health and

547
00:25:20,360 --> 00:25:23,040
National Institutes of Aging
through a wonderful SBIR grant.

548
00:25:23,520 --> 00:25:25,440
And we got about 90 older
adults.

549
00:25:25,440 --> 00:25:27,680
And this was done in Canada.
So a bunch of them spoke English

550
00:25:27,680 --> 00:25:28,800
and a bunch of them spoke
French.

551
00:25:28,800 --> 00:25:31,720
So that was fun.
And half of them did brain HQ

552
00:25:31,720 --> 00:25:35,160
exercises designed to improve,
again, that speed and accuracy

553
00:25:35,160 --> 00:25:37,640
of information processing.
And the other half of them just

554
00:25:37,640 --> 00:25:39,520
did ordinary computer games,
right?

555
00:25:39,520 --> 00:25:41,880
The kind of thing you might just
kill time on your phone while

556
00:25:41,880 --> 00:25:43,600
you're on the subway or waiting
in line.

557
00:25:44,160 --> 00:25:46,960
And it's a wonderful comparison
because both of those things

558
00:25:46,960 --> 00:25:50,080
involve attention, right?
Both of them involve thinking,

559
00:25:50,360 --> 00:25:53,160
but only one of them is really
designed to drive brain

560
00:25:53,160 --> 00:25:56,440
plasticity, to reorganize the
brain, to make it faster and

561
00:25:56,440 --> 00:25:58,400
more accurate.
You might think of the ordinary

562
00:25:58,400 --> 00:26:01,000
games as just keeping your brain
busy, so to speak.

563
00:26:01,520 --> 00:26:04,520
But what's nice is both groups,
you can tell them quite

564
00:26:04,520 --> 00:26:07,640
legitimately, hey, we're testing
a brain training program, right?

565
00:26:07,640 --> 00:26:09,640
One of them happens to do Brain
HQ, one of them happens to do

566
00:26:09,640 --> 00:26:11,520
computer games.
But everyone thinks, hey, I'm

567
00:26:11,520 --> 00:26:12,960
doing something good for my
brain.

568
00:26:12,960 --> 00:26:15,400
So you can maintain a very nice
blind in the study.

569
00:26:15,400 --> 00:26:16,880
Everyone thinks they're doing
something good.

570
00:26:17,320 --> 00:26:19,120
So then these researchers
measured everyone's

571
00:26:19,120 --> 00:26:22,080
acetylcholine before training.
They then trained for about 10

572
00:26:22,080 --> 00:26:24,640
weeks and then they measured
their acetylcholine afterwards.

573
00:26:25,040 --> 00:26:26,920
The study team did this for two
years.

574
00:26:26,920 --> 00:26:28,840
And you're not allowed to look
at the data along the way.

575
00:26:28,840 --> 00:26:31,360
You're just working really hard
and finding these people and

576
00:26:31,360 --> 00:26:33,080
doing this PET imaging and
you're going to see what

577
00:26:33,080 --> 00:26:35,080
happens.
And how much training did they

578
00:26:35,080 --> 00:26:38,240
do over the course of the study?
Both groups trained about 30

579
00:26:38,240 --> 00:26:39,800
minutes a day, seven days a
week.

580
00:26:39,800 --> 00:26:42,760
So we tried to really set it up
as a habit for them, but none

581
00:26:42,760 --> 00:26:44,840
the less, an amount of time you
can fit into your life.

582
00:26:45,200 --> 00:26:47,120
And both groups actually
complied with the training

583
00:26:47,120 --> 00:26:49,160
pretty well, right?
Everyone misses a few days, but

584
00:26:49,160 --> 00:26:51,000
you make them up and they really
stuck with it.

585
00:26:51,680 --> 00:26:53,120
And then what did we see at the
end?

586
00:26:53,200 --> 00:26:55,840
Just a fantastic and amazing
result.

587
00:26:56,120 --> 00:26:59,360
What we saw was that there were
dramatic improvements in the

588
00:26:59,360 --> 00:27:02,480
level of acetylcholine in the
folks who did the brain HQ

589
00:27:02,480 --> 00:27:05,320
training, and in particular in a
region of the brain called the

590
00:27:05,360 --> 00:27:08,760
anterior cingulate gyrus, a part
of the frontal cortex that's

591
00:27:08,760 --> 00:27:12,720
involved in complex attention
and decision making and

592
00:27:12,720 --> 00:27:15,600
executive function.
And those changes in the Brain

593
00:27:15,600 --> 00:27:17,920
HQ group were bigger than the
ones in the control group.

594
00:27:18,400 --> 00:27:21,120
And just to pop the champagne
moment, because this had never

595
00:27:21,120 --> 00:27:24,880
been shown before in humans that
the health of this incredibly

596
00:27:24,880 --> 00:27:28,120
important neurochemical system
could be modulated, right?

597
00:27:28,120 --> 00:27:30,520
A little bit like when I started
Graduate School, everyone's

598
00:27:30,520 --> 00:27:33,600
belief about that system was it
just wears out over time and

599
00:27:33,600 --> 00:27:34,800
there's nothing you can do about
it.

600
00:27:35,080 --> 00:27:37,240
And now we know for the first
time that's not true.

601
00:27:37,800 --> 00:27:39,960
And in fact, when those
researchers looked at almost

602
00:27:39,960 --> 00:27:43,240
every other brain region, they
saw the same pattern of effects,

603
00:27:43,240 --> 00:27:46,120
that there were improvements in
the folks who did Brain HQ

604
00:27:46,120 --> 00:27:48,960
across all the regions, the
cortex and the basal ganglia.

605
00:27:49,280 --> 00:27:51,600
And the folks who did those
computer games really showed no

606
00:27:51,600 --> 00:27:54,920
changes at all.
And that's just remarkable.

607
00:27:54,920 --> 00:27:57,080
You asked at the beginning a
little bit about hey, Brain

608
00:27:57,080 --> 00:27:59,200
fitness and we'll talk about
things people can do besides

609
00:27:59,200 --> 00:28:01,640
Brain HQ.
I do think that one issue we

610
00:28:01,640 --> 00:28:05,160
come across all the time is I do
crossword puzzles or I play

611
00:28:05,160 --> 00:28:07,120
Candy Crush.
Isn't that good enough for my

612
00:28:07,120 --> 00:28:09,800
brain?
And we have study after study

613
00:28:09,800 --> 00:28:12,760
where we use those as control
groups and we see that they

614
00:28:12,760 --> 00:28:14,200
don't drive cognitive
improvement.

615
00:28:14,200 --> 00:28:15,920
Then I can talk more about why
in a moment.

616
00:28:16,200 --> 00:28:19,640
But in this neurochemical study,
to show so clearly that even

617
00:28:19,640 --> 00:28:21,640
though these people have been
paying attention and using their

618
00:28:21,640 --> 00:28:24,520
memory and thinking, hey, man,
it just did not improve

619
00:28:24,520 --> 00:28:26,520
acetylcholine levels.
It did not improve the health of

620
00:28:26,520 --> 00:28:29,680
the brain this way.
That really teaches us something

621
00:28:29,680 --> 00:28:32,840
at a scientific level and a
practical level around, hey,

622
00:28:32,840 --> 00:28:36,400
what do you have to do to build
and strengthen brain health?

623
00:28:36,400 --> 00:28:39,400
It's not just keep your brain
busy with any old thing in the

624
00:28:39,400 --> 00:28:41,360
world.
It's really telling us that,

625
00:28:41,360 --> 00:28:44,280
hey, it's about activities that
make your brain faster and more

626
00:28:44,280 --> 00:28:45,880
accurate.
It's about activities that

627
00:28:45,880 --> 00:28:50,080
really adapt to your unique
brain and keep you frankly, on

628
00:28:50,080 --> 00:28:51,760
your toes.
And that threshold throughout

629
00:28:51,760 --> 00:28:54,560
training, hey, that's what
really drives and builds A

630
00:28:54,560 --> 00:28:57,320
healthier brain.
So incredibly exciting because

631
00:28:57,360 --> 00:28:59,720
hey, more acetylcholine of the
brain means better cognition,

632
00:28:59,720 --> 00:29:02,960
and probably means reduced risk
of dementia as well.

633
00:29:03,600 --> 00:29:06,480
What an exciting study.
Congratulations to you and your

634
00:29:06,480 --> 00:29:10,880
team and what a shift in the
research, but also what a time

635
00:29:10,880 --> 00:29:15,160
it takes to get to a study of
this type of level to shift a

636
00:29:15,160 --> 00:29:17,560
field as well.
So I want to at least

637
00:29:17,560 --> 00:29:19,960
acknowledge that.
But then also when I think about

638
00:29:19,960 --> 00:29:22,840
and just hearing it as well as
having have read some of these

639
00:29:22,840 --> 00:29:26,320
research studies over time, like
you said just years ago when

640
00:29:26,320 --> 00:29:30,920
you're useful field of view was
a big deal for dry and how that

641
00:29:30,920 --> 00:29:33,800
could change for brain HQ and
now to this.

642
00:29:33,800 --> 00:29:37,600
But it's also just seen and
collectively from what I've read

643
00:29:37,600 --> 00:29:40,280
over the years in my own
collective training, is how

644
00:29:40,280 --> 00:29:46,760
demanding our brain is of the
level that it needs in order to

645
00:29:46,760 --> 00:29:50,800
change and to pivot, that it's
just not the bare minimum.

646
00:29:50,800 --> 00:29:54,520
It seems that our homegrown the
bar on us, but we have the

647
00:29:54,520 --> 00:29:57,080
ability to do it.
I think it's like this balance

648
00:29:57,120 --> 00:30:01,000
of what I'm bringing in, what I
keep thinking about coming from

649
00:30:01,000 --> 00:30:04,240
the background and behavioral
health and cognitive psychology

650
00:30:04,240 --> 00:30:06,640
is our brains are a little bit
finicky.

651
00:30:06,840 --> 00:30:09,800
It's not just this low
threshold.

652
00:30:09,840 --> 00:30:11,600
It really keeps raising this
bar.

653
00:30:11,600 --> 00:30:15,640
And as you talk about what Brain
HQ is challenged to do is we

654
00:30:15,640 --> 00:30:18,880
need this level of challenge,
but we can get there.

655
00:30:19,160 --> 00:30:22,760
And our brains almost demand
that from us to do that change

656
00:30:22,760 --> 00:30:26,600
and to drive that plasticity.
You're absolutely right on the

657
00:30:26,600 --> 00:30:29,840
positive science, and the study
was led by my colleague Dr. Mana

658
00:30:29,840 --> 00:30:32,160
Tara.
And as you design a study like

659
00:30:32,160 --> 00:30:34,280
this, you have to make a million
little decisions and every

660
00:30:34,280 --> 00:30:37,120
single one of them, you have to
be like, is this going to affect

661
00:30:37,160 --> 00:30:39,320
the validity and then the
likelihood of success in the

662
00:30:39,320 --> 00:30:41,240
study.
And one of the things that

663
00:30:41,240 --> 00:30:44,160
Doctor Tara was very committed
to was, hey, that intensity of

664
00:30:44,160 --> 00:30:47,160
training seven days a week, 30
minutes a day, She wanted that

665
00:30:47,160 --> 00:30:49,000
because she wanted people to set
up a habit.

666
00:30:49,000 --> 00:30:51,320
She thought, hey, fewer people
will miss training if hey, man,

667
00:30:51,320 --> 00:30:52,680
I just, I'm doing this every
day.

668
00:30:53,200 --> 00:30:56,320
She, like you just said, the
very strong belief and we all

669
00:30:56,320 --> 00:30:59,000
believed it and she turned out
to be right, which is, hey, you

670
00:30:59,000 --> 00:31:02,240
really do have to push the brain
in this way in order to drive

671
00:31:02,240 --> 00:31:04,680
these kinds of health and this
kind of structural remodeling on

672
00:31:04,680 --> 00:31:06,800
the brain.
And you're absolutely right.

673
00:31:06,920 --> 00:31:09,600
And sometimes I think we think
I'll just do a little more.

674
00:31:09,760 --> 00:31:12,200
I read books, I'm going to do a
crossword puzzle once a week.

675
00:31:12,200 --> 00:31:14,440
Isn't that enough?
And I wish it were.

676
00:31:14,960 --> 00:31:16,520
That would be wonderful news,
right?

677
00:31:17,040 --> 00:31:20,200
But again, like exercise, if
you're going to meaningfully

678
00:31:20,200 --> 00:31:22,560
change your heart health, right?
If you're going to lower your

679
00:31:22,560 --> 00:31:26,360
blood pleasure or manage your
cholesterol, it's not just go

680
00:31:26,360 --> 00:31:29,480
out for a little stroll once or
twice a week for 15 minutes and

681
00:31:29,480 --> 00:31:31,440
enjoy the nature.
You're going to need to get out

682
00:31:31,440 --> 00:31:34,280
there and sweat a little bit to
change your body in that way and

683
00:31:34,280 --> 00:31:35,840
changing the brains exactly the
right way.

684
00:31:36,080 --> 00:31:38,520
But the good news is that's
actually extremely feasible.

685
00:31:38,640 --> 00:31:40,240
Flip the thought around for a
moment.

686
00:31:40,520 --> 00:31:42,760
My gosh.
In that study, what they showed

687
00:31:42,760 --> 00:31:46,360
was they improved acetylcholine
levels by about 2 1/2%, which is

688
00:31:46,360 --> 00:31:50,160
about 10 years of brain aging.
So they got 10 years of brain

689
00:31:50,160 --> 00:31:52,960
aging benefit out of 10 weeks of
brain training.

690
00:31:53,280 --> 00:31:57,000
Like that's not really a lot
when you get right down to it.

691
00:31:57,240 --> 00:32:01,200
It's remarkable that we can
remodel and restructure the

692
00:32:01,200 --> 00:32:04,800
brain so dramatically, frankly,
in just 10 weeks, a day, the 10

693
00:32:04,800 --> 00:32:08,040
weeks of training, 30 minutes.
And 30 minutes a day, which I

694
00:32:08,120 --> 00:32:11,520
think for that point too is
that's feasible for most of us.

695
00:32:11,520 --> 00:32:15,000
If you laid that out and you
said this is the investment.

696
00:32:15,800 --> 00:32:19,080
Most of us, I think it always
comes down to with it's money,

697
00:32:19,080 --> 00:32:21,120
time and your energy for.
The cost?

698
00:32:21,520 --> 00:32:25,840
Of what or the investment of
what grain HQ is and your time

699
00:32:25,840 --> 00:32:28,560
and your energy that is all very
feasible.

700
00:32:28,560 --> 00:32:32,600
It is not this out of the reach
moment for many people.

701
00:32:32,600 --> 00:32:34,960
Now if you flipped it around
where before when a lot of the

702
00:32:34,960 --> 00:32:37,840
times when it used to be back in
the day they computerized

703
00:32:38,040 --> 00:32:40,760
training threshold was two 2 1/2
hours a day.

704
00:32:40,760 --> 00:32:44,120
Most of us would be like, I'm
not even going to start because

705
00:32:44,120 --> 00:32:46,760
I can't commit to this.
Because I can't commit to.

706
00:32:47,240 --> 00:32:48,400
This.
This is feasible.

707
00:32:48,400 --> 00:32:50,960
This is a very feasible
commitment, especially when you

708
00:32:50,960 --> 00:32:52,800
look at that kind of magnitude
of benefit.

709
00:32:53,360 --> 00:32:58,680
Yeah, 10 years, most of us would
be like, where can I sign up?

710
00:32:58,680 --> 00:33:01,280
So I'm going to ask you now too
on this.

711
00:33:01,320 --> 00:33:03,800
What else are some of the
reasonable recommendations or

712
00:33:03,800 --> 00:33:07,200
takeaways you have for people
around this concept of brain

713
00:33:07,200 --> 00:33:11,360
fitness or wanting to invest in
their cognitive health and care?

714
00:33:12,040 --> 00:33:14,120
I'll say a couple things because
as I mentioned, when we started

715
00:33:14,120 --> 00:33:16,520
this work, we really thought of
this as building cognitive

716
00:33:16,520 --> 00:33:19,360
training exercises.
And of course we got very good

717
00:33:19,360 --> 00:33:21,080
at that and we've gotten
wonderful results.

718
00:33:21,400 --> 00:33:24,360
But I, I would say my thinking
as a scientist and everyone here

719
00:33:24,360 --> 00:33:26,920
at Brain HQ is thinking has
really changed and grown over

720
00:33:26,920 --> 00:33:28,160
the years, really two important
ways.

721
00:33:28,520 --> 00:33:32,160
One of which is, hey, there's
just a lot of evidence for a lot

722
00:33:32,160 --> 00:33:34,760
of things that can help improve
brain health at this point.

723
00:33:34,960 --> 00:33:37,240
And obviously we're going to
recommend brain training.

724
00:33:37,240 --> 00:33:40,240
It works really well, but it's
very clear at this point that

725
00:33:40,280 --> 00:33:42,960
hey, physical exercise helps
improve brain health, probably

726
00:33:42,960 --> 00:33:46,120
by releasing growth factors like
BDNF and improving heart health,

727
00:33:46,120 --> 00:33:47,520
which is good for the brain as
well.

728
00:33:47,960 --> 00:33:50,880
It's incredibly clear that
maintaining good sleep habits

729
00:33:50,880 --> 00:33:53,160
contributes to brain health
because, hey, when you sleep,

730
00:33:53,160 --> 00:33:56,000
your brain cleans itself and
everything you learned during

731
00:33:56,000 --> 00:33:58,240
the day gets rehearsed while
you're sleeping through a

732
00:33:58,240 --> 00:34:00,800
plastic brain process and sinks
in, right?

733
00:34:01,160 --> 00:34:04,320
The role of social contact has
been incredibly clear.

734
00:34:04,320 --> 00:34:07,320
It's very clear that loneliness
is a risk factor for poor brain

735
00:34:07,320 --> 00:34:10,000
health and that people who build
and maintain good social

736
00:34:10,000 --> 00:34:11,639
relationships have better brain
health.

737
00:34:12,040 --> 00:34:14,719
And So what that's really taught
us, and I think most people in

738
00:34:14,719 --> 00:34:18,080
the field at this point is, hey,
we need to be thinking about all

739
00:34:18,080 --> 00:34:21,120
kinds of real practical things
that people can do in their

740
00:34:21,120 --> 00:34:22,520
life.
Whether it's computerized brain

741
00:34:22,520 --> 00:34:25,080
training like Brain HQ, or
whether it's moderate physical

742
00:34:25,080 --> 00:34:28,639
exercise or working on sleep
hygiene, or just making sure you

743
00:34:28,639 --> 00:34:30,560
stay in touch with your friends
and family.

744
00:34:30,800 --> 00:34:33,440
All those things are going to
contribute in their own way to

745
00:34:33,440 --> 00:34:36,040
better brain health.
And that's almost certainly the

746
00:34:36,040 --> 00:34:39,400
way that we are going to really
tackle the dementias crisis in

747
00:34:39,400 --> 00:34:42,159
America, right?
That we are going to figure out

748
00:34:42,159 --> 00:34:45,360
ways to build better brains and
keep them healthy before they go

749
00:34:45,360 --> 00:34:47,840
on to dementia.
The second thing I would say

750
00:34:47,840 --> 00:34:50,239
that our thinking has really
changed about is, like I said,

751
00:34:50,239 --> 00:34:52,760
when we started this, we thought
about building cognitive

752
00:34:52,760 --> 00:34:55,360
training exercises.
We don't think about it that way

753
00:34:55,360 --> 00:34:57,440
anymore.
We think about building brain

754
00:34:57,440 --> 00:35:00,120
training exercises.
And that may sound exactly the

755
00:35:00,120 --> 00:35:02,640
same, but there is a difference
here that's really become

756
00:35:02,640 --> 00:35:04,920
important to us and that's
guided other things we think

757
00:35:04,920 --> 00:35:08,040
people can do.
I no longer think of Brain HQ as

758
00:35:08,040 --> 00:35:10,720
training attention or memory or
executive function or what have

759
00:35:10,720 --> 00:35:13,000
you.
I think a brain HQ is providing

760
00:35:13,000 --> 00:35:16,720
speed and accuracy of training
to large parts of the brain and

761
00:35:16,720 --> 00:35:20,480
then building a healthier brain
as a biological system, right.

762
00:35:20,760 --> 00:35:23,760
And by making the brain
healthier, hey, you get

763
00:35:23,760 --> 00:35:27,240
cognitive improvement almost as
a side effect, if I may put it

764
00:35:27,240 --> 00:35:28,840
that way.
In the same way that the right

765
00:35:28,840 --> 00:35:31,360
kind of exercise builds A
healthier heart and then you

766
00:35:31,360 --> 00:35:33,840
like lower your cholesterol and
your blood pressure, doing the

767
00:35:33,840 --> 00:35:36,760
right kind of brain exercise
builds A healthier brain and

768
00:35:36,760 --> 00:35:39,200
then hey, you have sharper
attention and better speed and

769
00:35:39,200 --> 00:35:42,760
better working memory.
Now that's a kind of interesting

770
00:35:42,760 --> 00:35:45,200
change in our thinking and it
suggests some other things as

771
00:35:45,200 --> 00:35:46,480
well.
Hey, what are other things

772
00:35:46,480 --> 00:35:49,240
people can do in the real world
to train their speed and

773
00:35:49,240 --> 00:35:50,800
accuracy?
When you think about it that

774
00:35:50,800 --> 00:35:52,400
way, there's actually all kinds
of things.

775
00:35:52,400 --> 00:35:54,760
And then there's all kinds of
things that don't probably do

776
00:35:54,760 --> 00:35:56,960
that.
So I'll start with a negative

777
00:35:56,960 --> 00:35:58,160
right?
When people come to me and they

778
00:35:58,160 --> 00:35:59,880
say, hey, I do crossword puzzles
everyday.

779
00:35:59,880 --> 00:36:02,200
I say, hey, that's fantastic.
If you like crossword puzzles,

780
00:36:02,200 --> 00:36:05,640
knock yourself out, but they do
not make the brain faster and

781
00:36:05,640 --> 00:36:07,960
more accurate, right?
You feel like your brain's busy,

782
00:36:07,960 --> 00:36:09,960
like you're sitting there
thinking, feels like the wheels

783
00:36:09,960 --> 00:36:12,760
are turning.
But hey, there's not systematic

784
00:36:12,760 --> 00:36:15,360
input coming through the brain
that's making your brain faster

785
00:36:15,360 --> 00:36:16,880
and more accurate.
In that sense, you're not

786
00:36:16,880 --> 00:36:19,800
driving system wide brain
plasticity and improvements in

787
00:36:19,800 --> 00:36:21,480
brain health.
You're just thinking about

788
00:36:21,480 --> 00:36:23,560
words, which is great.
Again, if you like it, go right

789
00:36:23,560 --> 00:36:24,760
ahead.
I do a lot of things that I

790
00:36:24,760 --> 00:36:26,600
enjoy.
They're not necessarily training

791
00:36:26,600 --> 00:36:28,360
my brain.
But hey, if we're going to

792
00:36:28,440 --> 00:36:30,600
improve your brain health, we
need to go where the science

793
00:36:30,600 --> 00:36:32,000
takes us.
Same things for things like

794
00:36:32,000 --> 00:36:34,840
Wordle or Sudoku, all these
things where you're just sitting

795
00:36:34,840 --> 00:36:36,920
and thinking.
But what are some things you can

796
00:36:36,920 --> 00:36:38,480
do that improve your speed and
accuracy?

797
00:36:38,480 --> 00:36:40,920
Well, there's a lot of physical
fitness related things.

798
00:36:40,920 --> 00:36:43,120
Let's say you play ping pong or
tennis.

799
00:36:43,120 --> 00:36:46,040
In order to do that, your brain
has to become faster and more

800
00:36:46,040 --> 00:36:47,920
accurate.
You can't just wait all day when

801
00:36:47,920 --> 00:36:49,360
someone serves you the ping pong
ball.

802
00:36:49,560 --> 00:36:52,560
Your brain's got to respond
accurately and hit it back and

803
00:36:52,560 --> 00:36:54,800
so forth.
And hey, you can start an easy

804
00:36:54,840 --> 00:36:57,720
partners of ping pong and you
can get faster and so forth as

805
00:36:57,720 --> 00:36:59,280
time go on.
That's almost certainly good for

806
00:36:59,280 --> 00:37:01,320
your brain.
Or think about learning music.

807
00:37:01,400 --> 00:37:04,000
If you're going to learn to play
an instrument, a trumpet or a

808
00:37:04,000 --> 00:37:07,040
piano or whatever, you might
enjoy playing a recorder.

809
00:37:07,200 --> 00:37:09,920
That helps your brain become
faster and more accurate.

810
00:37:09,920 --> 00:37:12,360
You're hearing the notes you
have to play to keep up.

811
00:37:12,560 --> 00:37:14,120
You have to become more
accurate.

812
00:37:14,120 --> 00:37:17,000
You can start with easy music
and go on to more complex music.

813
00:37:17,400 --> 00:37:20,240
These kinds of activities, I
think almost certainly will be

814
00:37:20,240 --> 00:37:23,680
shown over time to help build
brain health, probably not as

815
00:37:23,680 --> 00:37:25,960
effectively as a targeted brain
training program.

816
00:37:25,960 --> 00:37:28,640
These are great things that
people can do to help maintain

817
00:37:28,640 --> 00:37:30,960
their brain health, really at
any age or in any physical

818
00:37:30,960 --> 00:37:33,440
condition.
I appreciate what you shared.

819
00:37:33,440 --> 00:37:36,480
I think so much more of what we
see in the broader brain Health

820
00:37:36,480 --> 00:37:38,960
Science space is it's never just
one thing.

821
00:37:39,240 --> 00:37:43,160
And no matter what area you
target, it spills over into

822
00:37:43,160 --> 00:37:45,240
another.
And I think that's the nice

823
00:37:45,240 --> 00:37:48,720
thing about the brain is it's
never just organized into one

824
00:37:48,720 --> 00:37:53,200
specific area is so robust.
It does seem to benefit more

825
00:37:53,200 --> 00:37:55,400
than one area.
And I think that's so much of

826
00:37:55,400 --> 00:37:58,760
the brain Health Science is even
when you target 1, like you

827
00:37:58,760 --> 00:38:02,320
said, you know your physical
health well, physical fitness

828
00:38:02,360 --> 00:38:05,120
benefits your brain health.
It's your brain fitness as well.

829
00:38:05,120 --> 00:38:08,160
So it's really hard to say when
you get very specific to one

830
00:38:08,160 --> 00:38:11,600
that it doesn't help these other
like social health.

831
00:38:11,680 --> 00:38:14,160
And like you mentioned with
sleep, they're all very

832
00:38:14,160 --> 00:38:16,480
interconnected on all very.
Interconnected, and they're all

833
00:38:16,480 --> 00:38:18,960
very interconnected because the
brain's all very interconnected.

834
00:38:18,960 --> 00:38:21,760
Every single part of the brain
is not a hop, skip and a jump

835
00:38:21,760 --> 00:38:23,040
from any other part of the
brain.

836
00:38:23,240 --> 00:38:25,240
And I think the other thing
that's just exciting about being

837
00:38:25,240 --> 00:38:28,040
in the field at this point of
time is, hey, what a hopeful and

838
00:38:28,040 --> 00:38:31,280
exciting time. 30 years ago,
there we were thinking that,

839
00:38:31,360 --> 00:38:33,480
that, hey, when you get old,
there's just nothing to be done.

840
00:38:33,480 --> 00:38:35,160
Might as well sit around and
watch television.

841
00:38:35,160 --> 00:38:37,840
Your brain's going to wear out.
Hey, your dad got Alzheimer's

842
00:38:37,840 --> 00:38:39,480
when he was 82.
You're probably going to get

843
00:38:39,480 --> 00:38:41,920
Alzheimer's when you're 82.
When that happens, I guess we'll

844
00:38:41,920 --> 00:38:44,520
put you in a home.
And what a different world we

845
00:38:44,520 --> 00:38:48,080
live in now where you can look
at all of this research from

846
00:38:48,080 --> 00:38:51,480
Brain HQ, from these other
things like exercise or sleep,

847
00:38:51,840 --> 00:38:55,120
and you can take action, right,
To help improve your brain

848
00:38:55,120 --> 00:38:58,240
health right now, to reduce your
risk of dementia, to have a

849
00:38:58,240 --> 00:39:00,960
sharper and happier brain.
And I think that's just

850
00:39:00,960 --> 00:39:03,320
tremendous.
I think 25 years, 10 years, 20

851
00:39:03,320 --> 00:39:05,000
years from now, we're going to
look back and we're going to

852
00:39:05,000 --> 00:39:07,960
say, hey, we were just coming
out of the dark ages, right?

853
00:39:08,280 --> 00:39:10,600
Can you believe we used to just
let people get old and tell

854
00:39:10,600 --> 00:39:13,560
them, hey, watch some TV reruns?
Can you believe we had vets

855
00:39:13,560 --> 00:39:16,080
coming back from the war with
blast injury and cognitive

856
00:39:16,080 --> 00:39:17,880
impairment?
And we just told them, go back

857
00:39:17,880 --> 00:39:19,560
to school, go back to work,
you'll be fine.

858
00:39:19,880 --> 00:39:22,240
Can you believe it that we had
people like schizophrenia and

859
00:39:22,240 --> 00:39:25,400
bipolar disorder and we didn't
figure out ways to improve the

860
00:39:25,400 --> 00:39:28,200
health of their brain in which
given they had obvious brain

861
00:39:28,200 --> 00:39:30,880
health based disorders.
So it's really exciting.

862
00:39:30,880 --> 00:39:32,840
It feels like we're coming out
of The Cave, we're coming into

863
00:39:32,840 --> 00:39:34,560
the sunlight.
We are getting more and more

864
00:39:34,560 --> 00:39:37,120
evidence based things that that
people can do to improve their

865
00:39:37,120 --> 00:39:39,000
brain health.
And just what a wonderful time

866
00:39:39,000 --> 00:39:40,840
to be part of the science and
part of this brain health

867
00:39:40,840 --> 00:39:43,400
community.
And I think it's always exciting

868
00:39:43,400 --> 00:39:46,120
to have conversations with
experts like yourself where we

869
00:39:46,120 --> 00:39:50,400
can pull this forward for other
people to hear about the science

870
00:39:50,400 --> 00:39:53,680
and how they can apply it.
So I'm going to ask you now for

871
00:39:53,680 --> 00:39:56,360
someone who might just be
starting, you know, thinking I

872
00:39:56,360 --> 00:39:59,120
want to start Brain HQ.
How do you suggest that they

873
00:39:59,120 --> 00:40:02,200
could get started with this type
of exercise or something along

874
00:40:02,200 --> 00:40:05,080
the lines of brain Fitness?
What words of encouragement

875
00:40:05,080 --> 00:40:08,200
would you like to give them?
First of all, anyone can come

876
00:40:08,200 --> 00:40:12,720
register for Brain HQ at
www.brainhq.com and when you

877
00:40:12,720 --> 00:40:15,960
register you get a free exercise
per day and hey, that's enough

878
00:40:15,960 --> 00:40:19,080
to train for a few days and get
a sense, hey do I like this?

879
00:40:19,080 --> 00:40:21,080
Is it for me?
Can I get my head around what

880
00:40:21,080 --> 00:40:24,040
this is all about?
And then subscribing is pretty

881
00:40:24,040 --> 00:40:27,000
inexpensive after that.
And so we want anyone to be able

882
00:40:27,000 --> 00:40:29,480
to take it out for a spin and
give it a try in that way.

883
00:40:29,480 --> 00:40:30,680
And that's what I would
recommend.

884
00:40:31,320 --> 00:40:35,000
And how do you recommend for
people to fit training into our

885
00:40:35,000 --> 00:40:37,160
busy lives?
If the 30 minutes at first

886
00:40:37,160 --> 00:40:39,840
sounds overwhelming, how do you
think it's a good place to get

887
00:40:39,840 --> 00:40:42,040
started?
The great news about Brain HQ is

888
00:40:42,040 --> 00:40:44,560
when you do it for the first
day, it's only 5 minutes, right?

889
00:40:44,680 --> 00:40:47,840
Gives you a little tutorial, you
do 1 introductory exercise and

890
00:40:47,840 --> 00:40:49,960
hey, you're done.
And then you come back the next

891
00:40:49,960 --> 00:40:52,600
day and you do the exercise you
already did, so you're familiar

892
00:40:52,600 --> 00:40:54,520
with it and then it introduces
one new one.

893
00:40:54,720 --> 00:40:56,840
So it ramps you on gently at
that point.

894
00:40:57,120 --> 00:41:00,000
And then what I'd say is that
study happened to be 30 minutes

895
00:41:00,000 --> 00:41:02,560
a day, seven days a week.
We've done other studies that

896
00:41:02,560 --> 00:41:05,240
were twice a week for an hour a
day.

897
00:41:05,520 --> 00:41:08,520
You can break it up in such a
way that it fits into your life.

898
00:41:08,520 --> 00:41:10,480
Now you do have to do a certain
amount of it, right?

899
00:41:10,480 --> 00:41:13,040
It's not magic.
Can't just do it once and then

900
00:41:13,040 --> 00:41:16,000
that's enough unfortunately.
If you can figure out a way to

901
00:41:16,000 --> 00:41:19,160
fit 1 1/2 or two hours of this
into your life each week,

902
00:41:19,160 --> 00:41:21,680
whether it's every day, a little
bit or a couple days more

903
00:41:21,680 --> 00:41:25,000
intensively, hey, you will be on
the road to better brain health

904
00:41:25,000 --> 00:41:26,800
and better brain fitness.
And in that sense, it's like

905
00:41:26,800 --> 00:41:28,880
exercise, right?
You do have to carve out a

906
00:41:28,880 --> 00:41:31,320
little time for it.
When I talk to people and they

907
00:41:31,320 --> 00:41:34,240
say, oh, I'll fit it in whenever
I have time, I know that I'm

908
00:41:34,240 --> 00:41:36,200
talking to someone who's not
going to do any brain training.

909
00:41:36,560 --> 00:41:39,080
But when I talk to someone who
says, OK, what I'm going to do

910
00:41:39,080 --> 00:41:42,040
is I'm going to do this for 20
minutes before I have lunch each

911
00:41:42,040 --> 00:41:43,440
day.
And then when I finish, it'll be

912
00:41:43,440 --> 00:41:45,560
time for lunch.
Or they fit it in to find a

913
00:41:45,560 --> 00:41:46,960
schedule.
The same way that you would make

914
00:41:46,960 --> 00:41:49,080
a physical fitness commitment,
like when am I going to, I go

915
00:41:49,080 --> 00:41:51,880
for a walk each day, I'm going
to have this regular time making

916
00:41:51,880 --> 00:41:53,400
that same commitment to brain
training.

917
00:41:53,400 --> 00:41:55,960
Again, whether it's 2 * a week
or whether it's five times a

918
00:41:55,960 --> 00:41:58,720
week or every day.
Find something that works for

919
00:41:58,720 --> 00:42:03,080
your life and then fit it in.
And then we have Brain HQ users

920
00:42:03,080 --> 00:42:04,680
who've done it every day for
years and years.

921
00:42:04,680 --> 00:42:06,920
It's simply amazing to look at
their training records.

922
00:42:07,400 --> 00:42:09,760
But hey, that the study we just
talked about was 10 weeks of

923
00:42:09,760 --> 00:42:12,560
training and we have lots of
users that train for a while,

924
00:42:12,560 --> 00:42:14,720
experience benefit.
And hey, they go away for a

925
00:42:14,720 --> 00:42:17,080
while, they get busy, other
things come up in their lives

926
00:42:17,160 --> 00:42:19,280
and a couple months later they
come back and they boost

927
00:42:19,280 --> 00:42:22,160
themselves back up.
And that's a perfectly great way

928
00:42:22,160 --> 00:42:25,280
to go about brain training.
I would never want anyone not to

929
00:42:25,280 --> 00:42:28,040
start because they thought I got
to do this everyday for the rest

930
00:42:28,040 --> 00:42:29,560
of my life.
And who's got time for that?

931
00:42:29,800 --> 00:42:31,960
Don't worry about that.
Just come and start.

932
00:42:32,160 --> 00:42:35,040
Do some, if you get busy, stop
for a while, then just come

933
00:42:35,040 --> 00:42:36,680
back.
And that's a great way to take

934
00:42:36,680 --> 00:42:39,320
care of your brain.
I think it's a nice way to think

935
00:42:39,320 --> 00:42:42,720
about holistically that brain
health, a lifelong journey for

936
00:42:42,720 --> 00:42:46,120
all of us and it's going to ebb
and flow and it's like our

937
00:42:46,120 --> 00:42:48,920
physical fitness, our brain
fitness is going to look like

938
00:42:48,920 --> 00:42:52,160
the same, but we can all make
small shifts to invest in our

939
00:42:52,160 --> 00:42:55,120
time and our energy.
It looks like that our time is

940
00:42:55,120 --> 00:42:58,400
winding down, but I want to make
sure I get a few final questions

941
00:42:58,400 --> 00:43:02,920
for you as an expert in brain
health and cognitive fitness and

942
00:43:02,920 --> 00:43:06,240
brain training.
What's your one non negotiable

943
00:43:06,240 --> 00:43:08,240
for taking care of your own
brain?

944
00:43:08,840 --> 00:43:11,400
Of course, I'm going to say
brain training with Brain HQ.

945
00:43:11,600 --> 00:43:14,160
We built it, we tested it.
I love it.

946
00:43:14,320 --> 00:43:16,080
It's always got raised.
It's getting better.

947
00:43:16,080 --> 00:43:19,480
But yeah, I trained my brain
with Brain HQ on a regular basis

948
00:43:19,480 --> 00:43:22,360
and today it's good for me.
I have my own brain health

949
00:43:22,360 --> 00:43:25,120
stories.
I was driving up to Lake Tahoe a

950
00:43:25,120 --> 00:43:28,640
winter or two ago at night with
my family in the car and all of

951
00:43:28,640 --> 00:43:31,160
a sudden a deer literally jumped
off the edge of the highway and

952
00:43:31,160 --> 00:43:32,840
onto the road.
And before I even noticed what

953
00:43:32,840 --> 00:43:34,840
was happening, I had stepped on
the brake and stopped the car.

954
00:43:34,840 --> 00:43:36,680
I didn't even know why I was
stopping the car.

955
00:43:36,760 --> 00:43:39,120
And then when the car stopped, I
could finally see the deer.

956
00:43:39,360 --> 00:43:42,320
And I'm absolutely certain that
the reason my visual system was

957
00:43:42,320 --> 00:43:44,920
working so well, even under very
challenging conditions.

958
00:43:45,200 --> 00:43:47,560
Done quite a bit of Brain HQ
training over my years.

959
00:43:47,760 --> 00:43:50,480
Yeah, Brain HQ is my is my one
non negotiable.

960
00:43:50,720 --> 00:43:54,160
If I had to pick a second one
that wasn't that, I would say

961
00:43:54,160 --> 00:43:57,560
avoiding head injury.
And there are just so many ways

962
00:43:57,560 --> 00:43:59,800
that people are at risk for a
concussion, right?

963
00:43:59,960 --> 00:44:02,520
You're riding your bike, you're
driving dangerously in a car,

964
00:44:02,560 --> 00:44:05,640
you trip over something and
being more careful about the

965
00:44:05,640 --> 00:44:08,240
kinds of things we do and then
wearing helmets and stuff like

966
00:44:08,240 --> 00:44:10,000
that when you're riding a bike
or motorcycle.

967
00:44:10,240 --> 00:44:12,440
Avoiding head injury is
incredibly important for good

968
00:44:12,440 --> 00:44:15,360
brain health over life.
And I'm glad you shared both of

969
00:44:15,360 --> 00:44:16,880
those.
One, thank you for sharing your

970
00:44:16,880 --> 00:44:19,440
personal experience.
But also I think the head injury

971
00:44:19,440 --> 00:44:22,360
is 1.
We tend to overlook with adults.

972
00:44:22,440 --> 00:44:25,360
We think so much we go straight
to kids in the youth and we

973
00:44:25,360 --> 00:44:29,800
forget that it is for all ages
and just the quick safety things

974
00:44:29,800 --> 00:44:34,160
we can do for everyone from all
ages and stages of life.

975
00:44:34,160 --> 00:44:37,040
If there are things that have
piqued our listeners interest,

976
00:44:37,040 --> 00:44:39,720
where can they learn more about
you and follow your work?

977
00:44:40,040 --> 00:44:43,920
They can go to www.brainhq.com,
which even if you're not

978
00:44:43,920 --> 00:44:46,360
registering for brain training,
got a wealth of information

979
00:44:46,360 --> 00:44:48,080
about brain health and brain
training.

980
00:44:48,240 --> 00:44:51,200
There's a wonderful blog there
that covers all kinds of aspects

981
00:44:51,200 --> 00:44:54,560
around brain health, whether
it's sleep or exercise or social

982
00:44:54,560 --> 00:44:57,040
contact.
We also have a fantastic YouTube

983
00:44:57,040 --> 00:44:59,800
channel you can go to,
youtube.com/brain HQ.

984
00:45:00,080 --> 00:45:03,520
There's dozens and dozens of
videos that explore the idea of

985
00:45:03,520 --> 00:45:06,280
brain HQ, what it is and how to
do it and how it works.

986
00:45:06,560 --> 00:45:09,000
There's also quite a few
webinars we've done on the

987
00:45:09,000 --> 00:45:11,240
science of brain health, both
about the details of brain

988
00:45:11,240 --> 00:45:13,360
training, but other aspects of
brain health as well.

989
00:45:13,360 --> 00:45:16,200
Whether it's again, sleep or
exercise or even more fun

990
00:45:16,200 --> 00:45:18,000
things.
We did a webinar about Brain HQ

991
00:45:18,000 --> 00:45:21,200
and magic recently where we had
a magician join us and talk

992
00:45:21,200 --> 00:45:23,840
about, hey, how do magicians
trick your memory and your

993
00:45:23,840 --> 00:45:26,160
attention.
Take advantage of your cognitive

994
00:45:26,280 --> 00:45:28,480
cognitive abilities to do
wonderful tricks.

995
00:45:28,480 --> 00:45:30,960
All kinds of fun stuff on the
YouTube channel and helpful and

996
00:45:30,960 --> 00:45:32,840
educational stuff about brain
health as well.

997
00:45:33,320 --> 00:45:36,240
And we will have those links
below for our listeners in the

998
00:45:36,240 --> 00:45:38,880
show notes.
And if you had one key message

999
00:45:38,880 --> 00:45:41,760
that you want our listeners to
take away from our conversation

1000
00:45:41,760 --> 00:45:43,600
today, what would you like it to
be?

1001
00:45:44,240 --> 00:45:48,880
Oh, I hope the key message is
you can actively take care of

1002
00:45:48,880 --> 00:45:51,240
and maintain and even improve
your brain health.

1003
00:45:51,600 --> 00:45:55,040
I hope that if people walk away
with one idea here, it's a brain

1004
00:45:55,040 --> 00:45:58,760
is not a computer chip.
It doesn't have RAM and memory,

1005
00:45:58,760 --> 00:46:02,000
and most importantly, it doesn't
wear out over time because your

1006
00:46:02,000 --> 00:46:04,480
brain is not a computer chip.
Because of brain plasticity, you

1007
00:46:04,480 --> 00:46:07,240
can do all kinds of everyday
things to help improve and

1008
00:46:07,240 --> 00:46:09,560
maintain your brain health.
And that's just an incredible

1009
00:46:09,560 --> 00:46:11,120
revolution.
We're in the middle right now.

1010
00:46:11,520 --> 00:46:14,280
So I hope that's a message of
hope and empowerment because

1011
00:46:14,280 --> 00:46:16,360
hey, our biggest challenge in
this field is inertia, right?

1012
00:46:16,360 --> 00:46:19,040
Most people aren't aware that
they can do something, so they

1013
00:46:19,040 --> 00:46:21,520
do nothing.
But thanks to your podcast and

1014
00:46:21,520 --> 00:46:23,520
all the great news that's been
out there, and let's get people

1015
00:46:23,520 --> 00:46:25,040
involved in taking care of their
brain health.

1016
00:46:25,040 --> 00:46:26,800
It's going to be good for them
and good for all of us.

1017
00:46:27,280 --> 00:46:30,680
Brain training isn't a trend,
it's a science backed way to

1018
00:46:30,680 --> 00:46:32,920
keep your mind strong and
resilient.

1019
00:46:33,200 --> 00:46:36,240
The right kind of brain
exercises can boost key brain

1020
00:46:36,240 --> 00:46:39,840
chemicals, improve membrane
thinking, and help protect

1021
00:46:39,840 --> 00:46:42,240
against age-related cognitive
decline.

1022
00:46:42,800 --> 00:46:45,440
The take away your brain
responds to challenge and

1023
00:46:45,440 --> 00:46:48,120
building your brain reserve is
something anyone can start

1024
00:46:48,120 --> 00:46:50,720
today.
I hope we're all encouraged to

1025
00:46:50,720 --> 00:46:53,040
go out and make your brain
sweat.

1026
00:46:53,360 --> 00:46:56,840
Doctor Henry Monka, thank you so
much for letting me pick your

1027
00:46:56,840 --> 00:46:59,840
brilliant brain on the Let's
Talk Brain Health Podcast.

1028
00:47:00,560 --> 00:47:04,280
Thank you for investing your
time and energy into your

1029
00:47:04,280 --> 00:47:07,800
personal brain care by listening
to today's episode of the Let's

1030
00:47:07,800 --> 00:47:11,200
Talk Brain Health Podcast.
I hope our conversation gave you

1031
00:47:11,200 --> 00:47:14,960
fresh insights, a bit of
infiration, or practical steps

1032
00:47:14,960 --> 00:47:18,240
that you can take on your own
personal brain care journey.

1033
00:47:18,680 --> 00:47:21,560
If you enjoyed today's
conversation, I'd like to ask

1034
00:47:21,560 --> 00:47:24,400
you to please share this episode
with someone who could benefit

1035
00:47:24,400 --> 00:47:26,880
from it or consider leaving us a
review.

1036
00:47:27,440 --> 00:47:30,680
If you have questions or a topic
in brain health you'd like me to

1037
00:47:30,680 --> 00:47:34,600
explore, please e-mail me
anytime at podcast at

1038
00:47:34,600 --> 00:47:38,280
virtualbrainhealthcenter.com.
I'd love to hear from you.

1039
00:47:38,600 --> 00:47:42,600
We have so many more exciting
topics ahead, and I can't wait

1040
00:47:42,600 --> 00:47:45,600
to continue this lifelong
journey of better brain health

1041
00:47:45,600 --> 00:47:48,880
together with you and our
growing virtual community.

1042
00:47:49,320 --> 00:47:52,400
Until next time, remember to
give your brain the care it

1043
00:47:52,400 --> 00:47:55,600
deserves and make your brain
health a priority.

Dr. Henry Mahncke, Ph.D. Profile Photo

CEO of Posit Science / Neuroscientist / Lead Developer of BrainHQ

Henry Mahncke, Ph.D. got his doctorate in neuroscience in the lab at UCSF that discovered the brain remains plastic – capable of chemical, physical and functional change – throughout life. After a stint consulting at McKinsey & Co,. he was recruited to lead the global team commercializing plasticity-based training at Posit Science, which makes BrainHQ. BrainHQ is the most scientifically validated brain training app on the market and has shown benefits in more than peer-reviewed 300 studies. Such benefits include gains in cognition (attention, speed, memory, decision-making), in quality of life (depressive symptoms, confidence and control, health-related quality of life) and in real-world activities (health outcomes, balance, driving, workplace activities). BrainHQ is used by leading health and Medicare Advantage plans, by pre-eminent medical centers, clinics, and communities, and by elite athletes, the military, and other organizations focused on peak performance.